| Group A | 14/09/2021 | Maccabi Tel Aviv | - | FC Alashkert | 4:1 |  |
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| Group A | 30/09/2021 | LASK | - | Maccabi Tel Aviv | 1:1 | ||||
| Group A | 21/10/2021 | HJK Helsinki | - | Maccabi Tel Aviv | 0:5 | |
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| Group A | 04/11/2021 | Maccabi Tel Aviv | - | HJK Helsinki | 3:0 |  |
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| Group A | 25/11/2021 | Maccabi Tel Aviv | - | LASK | 0:1 | ||||
| Group A | 09/12/2021 | FC Alashkert | - | Maccabi Tel Aviv | 1:1 | ||||
| Play-offs | 17/02/2022 | PSV Eindhoven | - | Maccabi Tel Aviv | 1:0 | ||||
| Play-offs | 24/02/2022 | Maccabi Tel Aviv | - | PSV Eindhoven | 1:1 |
Israel