| 7. Round | 23/09/2000 | KV Mechelen | - | Germinal Beerschot | 2:3 |  |
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| 8. Round | 01/10/2000 | Club Brugge KV | - | KV Mechelen | 5:2 | ||||
| 9. Round | 15/10/2000 | KRC Harelbeke | - | KV Mechelen | 1:0 | ||||
| 10. Round | 22/10/2000 | KV Mechelen | - | K.S.C. Eendracht Aalst | 4:1 | |
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| 11. Round | 28/10/2000 | Sint-Truidense VV | - | KV Mechelen | 1:0 | ||||
| 12. Round | 11/11/2000 | KV Mechelen | - | KVC Westerlo | 0:1 | |
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| 14. Round | 25/11/2000 | KV Mechelen | - | RSC Charleroi | 4:3 | ||||
| 16. Round | 09/12/2000 | KV Mechelen | - | RSC Anderlecht | 0:2 | ||||
| 17. Round | 16/12/2000 | Lierse SK (old) | - | KV Mechelen | 1:1 | ||||
| 18. Round | 20/12/2000 | KRC Genk | - | KV Mechelen | 3:1 |
Belgium