| 1. Round | 13/08/2021 | Cefn Druids | - | Connah's Quay Nomads | 0:2 | ||||
| 3. Round | 28/08/2021 | Cefn Druids | - | Barry Town United | 1:4 |  |
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| 4. Round | 31/08/2021 | Newtown AFC | - | Cefn Druids | 5:0 | ||||
| 5. Round | 10/09/2021 | Caernarfon Town | - | Cefn Druids | 3:0 | ||||
| 6. Round | 18/09/2021 | Cefn Druids | - | Penybont FC | 0:3 | ||||
| 7. Round | 02/10/2021 | Cardiff Metropolitan | - | Cefn Druids | 4:2 | ||||
| 8. Round | 09/10/2021 | Bala Town | - | Cefn Druids | 1:1 | ||||
| 11. Round | 29/10/2021 | Connah's Quay Nomads | - | Cefn Druids | 4:0 | ||||
| 12. Round | 05/11/2021 | Cefn Druids | - | Newtown AFC | 0:5 |
England