| 3. Round | 07/08/2016 | ACS Poli Timişoara | - | Pandurii Târgu Jiu | 1:3 |  |
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| 4. Round | 14/08/2016 | Pandurii Târgu Jiu | - | CFR Cluj | 1:1 | ||||
| 5. Round | 21/08/2016 | FC Voluntari | - | Pandurii Târgu Jiu | 0:0 | ||||
| 6. Round | 27/08/2016 | Pandurii Târgu Jiu | - | FC Steaua Bucureşti | 0:1 |  |
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| 7. Round | 09/09/2016 | Gaz Metan Mediaş | - | Pandurii Târgu Jiu | 1:3 | |
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| 8. Round | 16/09/2016 | Pandurii Târgu Jiu | - | ASA Târgu Mureş | 1:0 | ||||
| 9. Round | 20/09/2016 | CSM Politehnica Iași | - | Pandurii Târgu Jiu | 3:2 | |
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| 10. Round | 23/09/2016 | Pandurii Târgu Jiu | - | FC Viitorul Constanța | 0:1 | ||||
| 11. Round | 03/10/2016 | Concordia Chiajna | - | Pandurii Târgu Jiu | 0:0 | ||||
| 12. Round | 15/10/2016 | Pandurii Târgu Jiu | - | FC Botoşani | 2:1 | |
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| 13. Round | 22/10/2016 | Dinamo Bucureşti | - | Pandurii Târgu Jiu | 4:0 | ||||
| 14. Round | 29/10/2016 | CS Universitatea Craiova | - | Pandurii Târgu Jiu | 2:1 | |
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| 18. Round | 01/12/2016 | Pandurii Târgu Jiu | - | FC Voluntari | 1:1 | ||||
| 19. Round | 04/12/2016 | FC Steaua Bucureşti | - | Pandurii Târgu Jiu | 3:1 | ||||
| 20. Round | 10/12/2016 | Pandurii Târgu Jiu | - | Gaz Metan Mediaş | 2:5 | |
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