| 1. Round | 26/07/2021 | Botev Vratsa | - | Arda Kardzhali | 0:0 | ||||
| 2. Round | 31/07/2021 | Botev Vratsa | - | Levski Sofia | 2:0 | ||||
| 3. Round | 06/08/2021 | Tsarsko Selo Sofia | - | Botev Vratsa | 1:2 |  |
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| 4. Round | 16/08/2021 | Botev Vratsa | - | Botev Plovdiv | 1:1 | ||||
| 6. Round | 28/08/2021 | Botev Vratsa | - | Lokomotiv Plovdiv | 0:0 | ||||
| 7. Round | 12/09/2021 | CSKA 1948 Sofia | - | Botev Vratsa | 5:1 | ||||
| 8. Round | 19/09/2021 | Botev Vratsa | - | CSKA Sofia | 2:4 | ||||
| 9. Round | 26/09/2021 | PFC Ludogorets Razgrad | - | Botev Vratsa | 3:1 | ||||
| 10. Round | 02/10/2021 | Botev Vratsa | - | Lokomotiv Sofia | 2:2 | ||||
| 11. Round | 15/10/2021 | Pirin Blagoevgrad | - | Botev Vratsa | 3:1 | ||||
| 12. Round | 23/10/2021 | Botev Vratsa | - | Cherno More Varna | 0:0 | ||||
| 14. Round | 07/11/2021 | Arda Kardzhali | - | Botev Vratsa | 3:2 | ||||
| 15. Round | 22/11/2021 | Levski Sofia | - | Botev Vratsa | 0:0 | ||||
| 17. Round | 30/11/2021 | Botev Plovdiv | - | Botev Vratsa | 2:1 | ||||
| 18. Round | 04/12/2021 | Botev Vratsa | - | PFC Beroe | 1:0 |
Bulgaria