| 1. Round | 09/07/2017 | FC Milsami | - | Speranţa Nisporeni | 0:1 |  |
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| 2. Round | 15/07/2017 | Spicul Chișcăreni | - | Speranţa Nisporeni | 1:1 | ||||
| 3. Round | 24/07/2017 | Speranţa Nisporeni | - | FC Zaria | 2:4 | ||||
| 4. Round | 30/07/2017 | Dacia Chişinău | - | Speranţa Nisporeni | 2:1 | |
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| 5. Round | 04/08/2017 | Speranţa Nisporeni | - | FC Zimbru | 1:0 | ||||
| 6. Round | 12/08/2017 | CS Petrocub | - | Speranţa Nisporeni | 1:1 |  |
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| 8. Round | 25/08/2017 | FC Sfîntul Gheorghe | - | Speranţa Nisporeni | 2:1 | ||||
| 9. Round | 10/09/2017 | Speranţa Nisporeni | - | FC Sheriff | 1:2 | |
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| 10. Round | 16/09/2017 | Speranţa Nisporeni | - | FC Milsami | 1:3 | |
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| 12. Round | 30/09/2017 | FC Zaria | - | Speranţa Nisporeni | 3:0 | ||||
| 13. Round | 14/10/2017 | Speranţa Nisporeni | - | Dacia Chişinău | 0:0 | ||||
| 14. Round | 20/10/2017 | FC Zimbru | - | Speranţa Nisporeni | 2:1 | |
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| 15. Round | 29/10/2017 | Speranţa Nisporeni | - | CS Petrocub | 0:0 | ||||
| 16. Round | 04/11/2017 | Dinamo-Auto | - | Speranţa Nisporeni | 0:3 |  |
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| 17. Round | 18/11/2017 | Speranţa Nisporeni | - | FC Sfîntul Gheorghe | 0:0 | ||||
| 18. Round | 26/11/2017 | FC Sheriff | - | Speranţa Nisporeni | 0:1 | |
Russia