| 3. Round | 12/08/2021 | Isidro Metapán | - | CD Águila | 2:2 | ||||
| 4. Round | 14/08/2021 | Jocoro FC | - | Isidro Metapán | 1:0 | ||||
| 5. Round | 22/08/2021 | Isidro Metapán | - | Municipal Limeño | 1:0 | ||||
| 6. Round | 25/08/2021 | Platense Zacatecoluca | - | Isidro Metapán | 2:1 |  |
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| 8. Round | 12/09/2021 | Luis Ángel Firpo | - | Isidro Metapán | 1:1 | ||||
| 15. Round | 24/10/2021 | Isidro Metapán | - | Jocoro FC | 1:1 |  |
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| 18. Round | 06/11/2021 | Alianza | - | Isidro Metapán | 1:0 | ||||
| 19. Round | 14/11/2021 | Isidro Metapán | - | Luis Ángel Firpo | 2:1 | ||||
| 20. Round | 18/11/2021 | Once Municipal | - | Isidro Metapán | 1:1 | ||||
| 21. Round | 21/11/2021 | Isidro Metapán | - | FAS | 1:2 | |
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| 22. Round | 27/11/2021 | AD Chalatenango | - | Isidro Metapán | 1:0 | |
El Salvador