| Group B | 18/09/2022 | Alianza | - | Isidro Metapán | 2:2 | ||||
| Group B | 22/09/2022 | Isidro Metapán | - | Santa Tecla FC | 3:1 | ||||
| Group B | 25/09/2022 | Isidro Metapán | - | FAS | 2:2 | ||||
| Group B | 01/10/2022 | Atlético Marte | - | Isidro Metapán | 2:1 | ||||
| Group B | 05/10/2022 | Once Deportivo | - | Isidro Metapán | 1:1 | ||||
| Group B | 09/10/2022 | Isidro Metapán | - | Alianza | 1:0 | ||||
| Group B | 12/10/2022 | FAS | - | Isidro Metapán | 0:1 | ||||
| Group B | 20/10/2022 | Isidro Metapán | - | Once Deportivo | 2:1 | ||||
| Group B | 23/10/2022 | Isidro Metapán | - | Atlético Marte | 0:0 | ||||
| Quarter-finals | 28/10/2022 | Isidro Metapán | - | Jocoro FC | 1:1 | ||||
| Quarter-finals | 30/10/2022 | Jocoro FC | - | Isidro Metapán | 4:2 pso |
El Salvador