| 1. Round | 20/01/2022 | Olimpia | - | Real Sociedad | 4:2 | ||||
| 2. Round | 23/01/2022 | Marathón | - | Olimpia | 1:0 | ||||
| 4. Round | 10/02/2022 | Vida | - | Olimpia | 0:3 | ||||
| 5. Round | 13/02/2022 | Olimpia | - | Motagua | 1:1 | ||||
| 7. Round | 26/02/2022 | Lobos UPNFM | - | Olimpia | 0:3 | ||||
| 8. Round | 03/03/2022 | Platense | - | Olimpia | 0:3 | ||||
| 9. Round | 06/03/2022 | Olimpia | - | Victoria | 0:1 | ||||
| 10. Round | 13/03/2022 | Honduras Progreso | - | Olimpia | 1:3 | ||||
| 11. Round | 20/03/2022 | Olimpia | - | Marathón | 3:0 |  |
 |
||
| 13. Round | 07/04/2022 | Motagua | - | Olimpia | 1:2 | ||||
| 14. Round | 11/04/2022 | Real España | - | Olimpia | 1:0 | ||||
| 16. Round | 21/04/2022 | Real Sociedad | - | Olimpia | 0:1 | ||||
| 17. Round | 25/04/2022 | Olimpia | - | Lobos UPNFM | 0:1 | ||||
| 18. Round | 01/05/2022 | Victoria | - | Olimpia | 3:2 |
Honduras