2. Round | 16/07/2022 | Real Cartagena | - | Leones FC | 0:1 | ||||
4. Round | 30/07/2022 | Tigres FC | - | Leones FC | 1:1 | ||||
6. Round | 09/08/2022 | Barranquilla FC | - | Leones FC | 3:1 | ||||
7. Round | 16/08/2022 | Leones FC | - | Cúcuta Deportivo | 1:1 | ||||
8. Round | 22/08/2022 | Boca Juniors de Cali | - | Leones FC | 1:1 | ||||
10. Round | 02/09/2022 | Leones FC | - | Fortaleza FC | 1:1 | ||||
11. Round | 07/09/2022 | Atlético FC | - | Leones FC | 4:0 | ||||
16. Round | 08/10/2022 | Deportes Quindío | - | Leones FC | 3:2 |