2. Round | 12/08/2021 | Olimpia | - | Real España | 1:1 | ||||
3. Round | 15/08/2021 | Platense | - | Real España | 0:2 | ||||
4. Round | 22/08/2021 | Real España | - | Real Sociedad | 1:1 | ||||
14. Round | 17/10/2021 | Real España | - | Platense | 2:1 | ||||
1. Round | 21/10/2021 | Real España | - | Victoria | 1:1 | ||||
15. Round | 24/10/2021 | Lobos UPNFM | - | Real España | 1:2 | ||||
16. Round | 28/10/2021 | Real España | - | Honduras Progreso | 4:1 | ||||
17. Round | 30/10/2021 | Motagua | - | Real España | 0:1 | ||||
18. Round | 10/11/2021 | Real España | - | Vida | 2:1 |