| 4. Round | 03/11/2021 | CS Sfaxien | - | US Tataouine | 1:0 |  |
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| 5. Round | 06/11/2021 | US Tataouine | - | US Ben Guerdane | 1:2 | ||||
| 6. Round | 19/11/2021 | US Tataouine | - | Espérance de Tunis | 2:1 | ||||
| 7. Round | 22/11/2021 | ES Hammam Sousse | - | US Tataouine | 3:1 | ||||
| 9. Round | 26/02/2022 | US Tataouine | - | CS Hammam-Lif | 1:0 | ||||
| 10. Round | 09/03/2022 | ES Métlaoui | - | US Tataouine | 1:0 |
Tunisia