| 1. Round | 19/09/2020 | Mosta FC | - | Gudja United | 2:2 | ||||
| 2. Round | 26/09/2020 | Birkirkara FC | - | Mosta FC | 0:3 | ||||
| 3. Round | 01/10/2020 | Mosta FC | - | Balzan FC | 3:3 | ||||
| 7. Round | 30/10/2020 | Mosta FC | - | St. Luċija FC | 1:0 | ||||
| 8. Round | 22/11/2020 | Senglea Athletics | - | Mosta FC | 1:3 |  |
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| 9. Round | 29/11/2020 | Floriana FC | - | Mosta FC | 0:2 |  |
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| 10. Round | 05/12/2020 | Mosta FC | - | Tarxien Rainbows | 1:0 | ||||
| 11. Round | 09/12/2020 | Mosta FC | - | Valletta FC | 2:2 | |
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| 12. Round | 12/12/2020 | Lija Athletics FC | - | Mosta FC | 1:1 | ||||
| 13. Round | 19/12/2020 | Mosta FC | - | Zejtun Corinthians | 3:0 | ||||
| 6. Round | 22/12/2020 | Sirens FC | - | Mosta FC | 2:2 | |
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| 14. Round | 06/01/2021 | Sliema Wanderers | - | Mosta FC | 1:3 | ||||
| 15. Round | 10/01/2021 | Hamrun Spartans | - | Mosta FC | 3:1 | ||||
| 17. Round | 24/01/2021 | Mosta FC | - | Birkirkara FC | 0:1 | ||||
| 18. Round | 29/01/2021 | Balzan FC | - | Mosta FC | 4:1 | |
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| 20. Round | 13/02/2021 | Hibernians FC | - | Mosta FC | 2:0 | ||||
| 16. Round | 17/02/2021 | Gudja United | - | Mosta FC | 0:1 | ||||
| 21. Round | 21/02/2021 | Mosta FC | - | Sirens FC | 0:0 | ||||
| 22. Round | 27/02/2021 | St. Luċija FC | - | Mosta FC | 2:3 |
Malta