| 1. Round | 14/08/2021 | Mosta FC | - | Birkirkara FC | 0:3 | ||||
| 2. Round | 20/08/2021 | Sirens FC | - | Mosta FC | 1:1 | ||||
| 5. Round | 26/09/2021 | Mosta FC | - | Balzan FC | 2:1 | ||||
| 6. Round | 17/10/2021 | St. Luċija FC | - | Mosta FC | 2:2 | ||||
| 8. Round | 31/10/2021 | Sliema Wanderers | - | Mosta FC | 2:3 |  |
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| 9. Round | 20/11/2021 | Mosta FC | - | Gżira United | 2:2 | ||||
| 10. Round | 27/11/2021 | Valletta FC | - | Mosta FC | 3:1 | ||||
| 11. Round | 04/12/2021 | Mosta FC | - | Gudja United | 0:3 | ||||
| 12. Round | 12/12/2021 | Birkirkara FC | - | Mosta FC | 2:2 | ||||
| 14. Round | 17/01/2022 | Hamrun Spartans | - | Mosta FC | 2:1 | ||||
| 15. Round | 22/01/2022 | Mosta FC | - | Hibernians FC | 1:1 | ||||
| 16. Round | 29/01/2022 | Balzan FC | - | Mosta FC | 2:3 |  |
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| 17. Round | 05/02/2022 | Mosta FC | - | St. Luċija FC | 1:0 | ||||
| 19. Round | 20/02/2022 | Mosta FC | - | Sliema Wanderers | 1:0 | ||||
| 20. Round | 27/02/2022 | Gżira United | - | Mosta FC | 3:4 |
Malta