| 1. Round | 16/09/2000 | Paniliakos Pyrgos | - | Panionios GSS | 1:1 | ||||
| 3. Round | 30/09/2000 | Paniliakos Pyrgos | - | OFI Heraklion | 0:0 | ||||
| 7. Round | 18/11/2000 | Skoda Xanthi | - | Paniliakos Pyrgos | 2:0 | ||||
| 15. Round | 20/01/2001 | Paniliakos Pyrgos | - | PAS Giannina | 1:0 | ||||
| 16. Round | 27/01/2001 | Panionios GSS | - | Paniliakos Pyrgos | 0:1 | ||||
| 17. Round | 03/02/2001 | Paniliakos Pyrgos | - | Aris Saloniki | 1:2 | ||||
| 19. Round | 17/02/2001 | Olympiakos Piraeus | - | Paniliakos Pyrgos | 2:0 | ||||
| 20. Round | 23/02/2001 | Paniliakos Pyrgos | - | Panathinaikos | 0:3 |  |
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| 22. Round | 10/03/2001 | Paniliakos Pyrgos | - | Skoda Xanthi | 1:0 | ||||
| 24. Round | 31/03/2001 | Paniliakos Pyrgos | - | Athinaikos | 3:0 | |
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| 25. Round | 07/04/2001 | Ethnikos Asteras | - | Paniliakos Pyrgos | 1:1 | ||||
| 26. Round | 19/04/2001 | Paniliakos Pyrgos | - | Ionikos Nikea | 1:0 | ||||
| 27. Round | 28/04/2001 | Paniliakos Pyrgos | - | AEK Athen | 0:3 | ||||
| 28. Round | 05/05/2001 | Panachaiki GE | - | Paniliakos Pyrgos | 3:0 | |
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| 29. Round | 19/05/2001 | Paniliakos Pyrgos | - | PS Kalamata | 3:1 | |
Greece