| 7. Round | 30/08/2021 | Santos Laguna | - | FC Juárez | 2:0 | ||||
| 8. Round | 11/09/2021 | Club Tijuana | - | Santos Laguna | 2:1 | ||||
| 9. Round | 20/09/2021 | Santos Laguna | - | Puebla FC | 1:1 | ||||
| 10. Round | 27/09/2021 | Santos Laguna | - | CF Monterrey | 1:2 | ||||
| 12. Round | 03/10/2021 | Santos Laguna | - | Mazatlán FC | 1:0 |  |
|||
| 13. Round | 17/10/2021 | CF Pachuca | - | Santos Laguna | 1:1 | ||||
| 14. Round | 20/10/2021 | CF América | - | Santos Laguna | 2:1 | ||||
| 15. Round | 25/10/2021 | Santos Laguna | - | Deportivo Toluca | 2:2 |
Mexico
Lebanon