| 1. Round | 21/08/2021 | Paphos FC | - | APOEL Nikosia | 4:0 | ||||
| 2. Round | 13/09/2021 | APOEL Nikosia | - | Olympiakos Nikosia | 0:1 | ||||
| 3. Round | 19/09/2021 | Apollon Limassol | - | APOEL Nikosia | 2:1 | ||||
| 5. Round | 03/10/2021 | Anorthosis Famagusta | - | APOEL Nikosia | 2:1 |  |
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| 6. Round | 18/10/2021 | APOEL Nikosia | - | Ethnikos Achna | 2:1 | ||||
| 7. Round | 24/10/2021 | Aris Limassol | - | APOEL Nikosia | 0:1 |  |
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| 8. Round | 30/10/2021 | Doxa Katokopias | - | APOEL Nikosia | 2:2 | ||||
| 9. Round | 06/11/2021 | APOEL Nikosia | - | AEL Limassol | 3:0 | |
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| 10. Round | 22/11/2021 | AEK Larnaca | - | APOEL Nikosia | 0:0 | ||||
| 14. Round | 18/12/2021 | APOEL Nikosia | - | Apollon Limassol | 1:1 | ||||
| 11. Round | 26/12/2021 | APOEL Nikosia | - | Omonia Nikosia | 4:2 | |
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| 17. Round | 15/01/2022 | Ethnikos Achna | - | APOEL Nikosia | 0:3 | |
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| 18. Round | 23/01/2022 | APOEL Nikosia | - | Aris Limassol | 1:1 | ||||
| 20. Round | 06/02/2022 | AEL Limassol | - | APOEL Nikosia | 2:3 | |
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| 15. Round | 09/02/2022 | PAEEK | - | APOEL Nikosia | 1:3 | ||||
| 21. Round | 14/02/2022 | APOEL Nikosia | - | AEK Larnaca | 1:0 | |
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| 16. Round | 17/02/2022 | APOEL Nikosia | - | Anorthosis Famagusta | 0:2 | ||||
| 22. Round | 25/02/2022 | Omonia Nikosia | - | APOEL Nikosia | 2:4 | |
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Georgia