| 2. Round | 19/09/2021 | Apollon Smyrnis | - | Volos NFC | 1:3 | ||||
| 5. Round | 02/10/2021 | Aris Saloniki | - | Apollon Smyrnis | 0:0 | ||||
| 9. Round | 06/11/2021 | Apollon Smyrnis | - | AEK Athen | 2:2 | ||||
| 11. Round | 27/11/2021 | Apollon Smyrnis | - | Lamia | 0:0 | ||||
| 13. Round | 12/01/2022 | Apollon Smyrnis | - | OFI Heraklion | 0:3 | ||||
| 18. Round | 15/01/2022 | Apollon Smyrnis | - | Aris Saloniki | 0:0 | ||||
| 15. Round | 19/01/2022 | Volos NFC | - | Apollon Smyrnis | 1:0 | ||||
| 19. Round | 24/01/2022 | Asteras Tripolis | - | Apollon Smyrnis | 1:0 | ||||
| 20. Round | 30/01/2022 | PAS Giannina | - | Apollon Smyrnis | 2:0 | ||||
| 21. Round | 02/02/2022 | Apollon Smyrnis | - | PAOK Saloniki | 0:2 | ||||
| 22. Round | 06/02/2022 | AEK Athen | - | Apollon Smyrnis | 3:0 | ||||
| 24. Round | 20/02/2022 | Lamia | - | Apollon Smyrnis | 1:2 | ||||
| 17. Round | 23/02/2022 | Ionikos Nikea | - | Apollon Smyrnis | 4:0 | ||||
| 26. Round | 06/03/2022 | OFI Heraklion | - | Apollon Smyrnis | 2:0 |
Cyprus