| 1. Round | 27/08/2021 | SPAL 2013 Ferrara [Youth] | - | Sampdoria [Youth] | 1:0 | ||||
| 2. Round | 13/09/2021 | SPAL 2013 Ferrara [Youth] | - | Hellas Verona [Youth] | 0:0 | ||||
| 3. Round | 18/09/2021 | Empoli FC [Youth] | - | SPAL 2013 Ferrara [Youth] | 6:0 | ||||
| 4. Round | 26/09/2021 | SPAL 2013 Ferrara [Youth] | - | Cagliari Calcio [Youth] | 1:1 | ||||
| 5. Round | 16/10/2021 | Bologna FC [Youth] | - | SPAL 2013 Ferrara [Youth] | 1:2 | ||||
| 6. Round | 22/10/2021 | SPAL 2013 Ferrara [Youth] | - | Genoa CFC [Youth] | 1:3 | ||||
| 7. Round | 01/11/2021 | Delfino Pescara [Youth] | - | SPAL 2013 Ferrara [Youth] | 0:1 |  |
|||
| 8. Round | 07/11/2021 | SPAL 2013 Ferrara [Youth] | - | Torino FC [Youth] | 0:2 |
Cyprus