| 17. Round | 30/07/2021 | Athlone Town | - | Treaty United | 1:4 | ||||
| 18. Round | 07/08/2021 | Cobh Ramblers | - | Athlone Town | 0:0 | ||||
| 19. Round | 13/08/2021 | UC Dublin | - | Athlone Town | 6:0 | ||||
| 20. Round | 20/08/2021 | Athlone Town | - | Galway United | 1:0 | ||||
| 21. Round | 03/09/2021 | Cork City | - | Athlone Town | 3:1 | ||||
| 22. Round | 10/09/2021 | Bray Wanderers | - | Athlone Town | 0:1 |  |
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| 23. Round | 24/09/2021 | Athlone Town | - | Wexford FC | 0:2 | ||||
| 25. Round | 08/10/2021 | Shelbourne FC | - | Athlone Town | 1:1 | ||||
| 26. Round | 15/10/2021 | Treaty United | - | Athlone Town | 1:1 | ||||
| 27. Round | 29/10/2021 | Athlone Town | - | Cobh Ramblers | 1:2 |
Ireland