| 19. Round | 19/02/2022 | FC Stade Nyonnais | - | FC Sion II | 4:2 | ||||
| 20. Round | 26/02/2022 | FC Sion II | - | AC Bellinzona | 1:4 | ||||
| 21. Round | 06/03/2022 | BSC Young Boys II | - | FC Sion II | 3:0 | ||||
| 22. Round | 12/03/2022 | FC Sion II | - | FC Chiasso | 0:1 | ||||
| 18. Round | 23/03/2022 | FC Sion II | - | FC Bavois | 0:0 | ||||
| 24. Round | 26/03/2022 | FC Sion II | - | FC Basel 1893 II | 1:2 | ||||
| 26. Round | 06/04/2022 | Etoile Carouge FC | - | FC Sion II | 4:1 | ||||
| 30. Round | 30/04/2022 | SC YF/Juventus Zürich | - | FC Sion II | 3:4 |
France