| 8. Round | 30/09/2000 | Lierse SK (old) | - | KRC Harelbeke | 4:1 | ||||
| 9. Round | 13/10/2000 | Lierse SK (old) | - | KRC Genk | 1:1 |  |
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| 10. Round | 21/10/2000 | KAA Gent | - | Lierse SK (old) | 2:3 | ||||
| 11. Round | 27/10/2000 | Lierse SK (old) | - | Excelsior Mouscron | 1:4 | ||||
| 12. Round | 11/11/2000 | Sporting Lokeren | - | Lierse SK (old) | 2:0 | ||||
| 15. Round | 02/12/2000 | Lierse SK (old) | - | Germinal Beerschot | 1:1 | ||||
| 17. Round | 16/12/2000 | Lierse SK (old) | - | KV Mechelen | 1:1 | ||||
| 18. Round | 20/12/2000 | Lierse SK (old) | - | K.S.C. Eendracht Aalst | 2:0 | ||||
| 19. Round | 20/01/2001 | Lierse SK (old) | - | Sint-Truidense VV | 2:1 | ||||
| 20. Round | 27/01/2001 | Lierse SK (old) | - | KVC Westerlo | 1:2 |  |
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| 21. Round | 03/02/2001 | KSK Beveren | - | Lierse SK (old) | 2:1 | ||||
| 24. Round | 03/03/2001 | Lierse SK (old) | - | RSC Anderlecht | 0:0 | ||||
| 27. Round | 31/03/2001 | Lierse SK (old) | - | KAA Gent | 2:0 |  |
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| 28. Round | 07/04/2001 | Excelsior Mouscron | - | Lierse SK (old) | 1:2 | ||||
| 29. Round | 14/04/2001 | Lierse SK (old) | - | Sporting Lokeren | 1:4 | ||||
| 30. Round | 21/04/2001 | Standard Liège | - | Lierse SK (old) | 3:2 | |
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| 31. Round | 28/04/2001 | Lierse SK (old) | - | RAA La Louviére | 1:2 |
Belgium