| 1. Round | 31/07/2010 | Sint-Truidense VV | - | Lierse SK (old) | 1:0 |  |
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| 2. Round | 06/08/2010 | Lierse SK (old) | - | Standard Liège | 1:4 | ||||
| 12. Round | 23/10/2010 | Lierse SK (old) | - | SV Zulte Waregem | 0:0 |  |
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| 14. Round | 06/11/2010 | Lierse SK (old) | - | Sporting Lokeren | 2:2 |  |
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| 15. Round | 13/11/2010 | Club Brugge KV | - | Lierse SK (old) | 2:0 | ||||
| 16. Round | 20/11/2010 | Lierse SK (old) | - | Sint-Truidense VV | 1:2 | ||||
| 20. Round | 18/12/2010 | Lierse SK (old) | - | KRC Genk | 1:1 | ||||
| 21. Round | 26/12/2010 | RSC Anderlecht | - | Lierse SK (old) | 6:0 | |
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| 23. Round | 22/01/2011 | Cercle Brugge | - | Lierse SK (old) | 3:0 | ||||
| 24. Round | 29/01/2011 | Lierse SK (old) | - | Sporting Charleroi | 1:0 | ||||
| 25. Round | 04/02/2011 | KAA Gent | - | Lierse SK (old) | 4:1 | |
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| 26. Round | 12/02/2011 | Lierse SK (old) | - | Germinal Beerschot | 2:2 | ||||
| 18. Round | 15/02/2011 | Lierse SK (old) | - | KV Mechelen | 2:1 | ||||
| 29. Round | 12/03/2011 | Sporting Lokeren | - | Lierse SK (old) | 1:1 |
Belgium