| 8. Round | 12/09/2021 | NK Istra 1961 | - | Hajduk Split | 1:3 | ||||
| 10. Round | 27/09/2021 | Hrvatski Dragovoljac | - | NK Istra 1961 | 0:1 | ||||
| 11. Round | 02/10/2021 | NK Istra 1961 | - | HNK Rijeka | 3:6 | ||||
| 13. Round | 24/10/2021 | Dinamo Zagreb | - | NK Istra 1961 | 1:1 | ||||
| 15. Round | 06/11/2021 | NK Osijek | - | NK Istra 1961 | 3:0 | ||||
| 16. Round | 20/11/2021 | NK Istra 1961 | - | HNK Šibenik | 3:4 |  |
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| 17. Round | 26/11/2021 | Hajduk Split | - | NK Istra 1961 | 4:0 | ||||
| 33. Round | 01/05/2022 | NK Osijek | - | NK Istra 1961 | 2:2 | ||||
| 35. Round | 14/05/2022 | Hajduk Split | - | NK Istra 1961 | 3:1 | ||||
| 36. Round | 20/05/2022 | NK Istra 1961 | - | Slaven Belupo | 3:1 |
Spain