| 6. Round | 18/09/2010 | FC Groningen | - | SBV Excelsior | 2:0 | ||||
| 7. Round | 25/09/2010 | PSV Eindhoven | - | FC Groningen | 1:1 |  |
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| 8. Round | 03/10/2010 | FC Twente | - | FC Groningen | 4:2 | ||||
| 9. Round | 17/10/2010 | FC Groningen | - | sc Heerenveen | 1:0 | ||||
| 10. Round | 23/10/2010 | NEC Nijmegen | - | FC Groningen | 3:2 | ||||
| 11. Round | 27/10/2010 | FC Groningen | - | ADO Den Haag | 3:1 |  |
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| 12. Round | 30/10/2010 | VVV-Venlo | - | FC Groningen | 3:5 | |
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| 13. Round | 06/11/2010 | FC Groningen | - | NAC Breda | 2:1 | ||||
| 14. Round | 14/11/2010 | Heracles Almelo | - | FC Groningen | 3:0 | ||||
| 15. Round | 21/11/2010 | FC Groningen | - | Feyenoord | 2:0 | ||||
| 18. Round | 12/12/2010 | FC Groningen | - | AZ Alkmaar | 2:0 | ||||
| 19. Round | 18/12/2010 | SBV Excelsior | - | FC Groningen | 2:2 | ||||
| 20. Round | 23/01/2011 | FC Groningen | - | FC Twente | 1:2 | ||||
| 21. Round | 30/01/2011 | sc Heerenveen | - | FC Groningen | 1:4 | ||||
| 25. Round | 27/02/2011 | Feyenoord | - | FC Groningen | 5:1 |
Uruguay
