| 27. Round | 30/01/2021 | Sheffield Wednesday | - | Preston North End | 1:0 | ||||
| 29. Round | 12/02/2021 | Blackburn Rovers | - | Preston North End | 1:2 |  |
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| 31. Round | 20/02/2021 | Cardiff City | - | Preston North End | 4:0 | ||||
| 32. Round | 24/02/2021 | Preston North End | - | Queens Park Rangers | 0:0 | ||||
| 33. Round | 27/02/2021 | Preston North End | - | Huddersfield Town | 3:0 |  |
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| 34. Round | 02/03/2021 | Millwall FC | - | Preston North End | 2:1 | ||||
| 35. Round | 06/03/2021 | Preston North End | - | AFC Bournemouth | 1:1 | |
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| 42. Round | 17/04/2021 | Stoke City | - | Preston North End | 0:0 | ||||
| 43. Round | 20/04/2021 | Preston North End | - | Derby County | 3:0 | ||||
| 45. Round | 01/05/2021 | Preston North End | - | Barnsley FC | 2:0 | ||||
| 46. Round | 08/05/2021 | Nottingham Forest | - | Preston North End | 1:2 |
Ireland