| 1. Round | 05/02/2023 | Montevideo City Torque | - | Danubio | 1:1 | ||||
| 2. Round | 12/02/2023 | Danubio | - | Liverpool | 1:1 |  |
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| 3. Round | 18/02/2023 | Cerro Largo | - | Danubio | 1:0 | ||||
| 4. Round | 26/02/2023 | Danubio | - | Plaza Colonia | 5:0 | ||||
| 5. Round | 03/03/2023 | Racing | - | Danubio | 1:1 | ||||
| 6. Round | 12/03/2023 | Danubio | - | CA Cerro | 1:0 | ||||
| 7. Round | 19/03/2023 | Boston River | - | Danubio | 3:3 |  |
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| 8. Round | 25/03/2023 | Danubio | - | Deportivo Maldonado | 4:0 | |
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| 9. Round | 31/03/2023 | River Plate | - | Danubio | 2:1 | ||||
| 10. Round | 09/04/2023 | Danubio | - | Nacional | 0:0 | ||||
| 11. Round | 15/04/2023 | Peñarol | - | Danubio | 2:0 | ||||
| 12. Round | 23/04/2023 | Fénix | - | Danubio | 2:1 | ||||
| 13. Round | 29/04/2023 | Danubio | - | Montevideo Wanderers | 0:2 | ||||
| 14. Round | 07/05/2023 | La Luz | - | Danubio | 3:1 | ||||
| 15. Round | 14/05/2023 | Danubio | - | Defensor Sporting | 1:1 | |
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