| 1. Round | 05/02/2022 | Montevideo City Torque | - | Cerro Largo | 1:1 | ||||
| 2. Round | 14/02/2022 | Montevideo Wanderers | - | Cerro Largo | 1:0 | ||||
| 3. Round | 18/02/2022 | Cerro Largo | - | Plaza Colonia | 0:5 | ||||
| 4. Round | 25/02/2022 | Boston River | - | Cerro Largo | 3:0 | ||||
| 5. Round | 05/03/2022 | River Plate | - | Cerro Largo | 1:1 | ||||
| 6. Round | 22/03/2022 | Cerro Largo | - | Cerrito | 1:0 | ||||
| 7. Round | 03/04/2022 | Fénix | - | Cerro Largo | 2:0 | ||||
| 8. Round | 08/04/2022 | Cerro Largo | - | Defensor Sporting | 0:0 | ||||
| 9. Round | 16/04/2022 | Albion | - | Cerro Largo | 2:1 | ||||
| 11. Round | 08/05/2022 | Danubio | - | Cerro Largo | 2:0 | ||||
| 14. Round | 28/05/2022 | Cerro Largo | - | Liverpool | 1:2 |
Argentina