| Preliminary | 18/03/2021 | Guaireña FC | - | River Plate | 1:2 | ||||
| Preliminary | 08/04/2021 | River Plate | - | Guaireña FC | 4:2 | ||||
| Group E | 23/04/2021 | River Plate | - | Corinthians SP | 0:0 | ||||
| Group E | 29/04/2021 | Sport Huancayo | - | River Plate | 1:2 | ||||
| Group E | 07/05/2021 | Peñarol | - | River Plate | 3:0 |  |
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| Group E | 14/05/2021 | River Plate | - | Sport Huancayo | 2:1 | ||||
| Group E | 27/05/2021 | Corinthians SP | - | River Plate | 4:0 |
Paraguay