| 2. Round | 19/07/2022 | Guaireña FC | - | Sportivo Ameliano | 3:1 | ||||
| 3. Round | 24/07/2022 | Club Olimpia | - | Guaireña FC | 2:1 | ||||
| 4. Round | 29/07/2022 | Guaireña FC | - | General Caballero DJLM | 1:2 | ||||
| 5. Round | 05/08/2022 | Resistencia SC | - | Guaireña FC | 1:2 |  |
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| 15. Round | 05/10/2022 | General Caballero DJLM | - | Guaireña FC | 0:0 | |
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| 16. Round | 10/10/2022 | Guaireña FC | - | Resistencia SC | 3:2 | ||||
| 17. Round | 14/10/2022 | 12 de Octubre de Itauguá | - | Guaireña FC | 0:0 | ||||
| 18. Round | 21/10/2022 | Guaireña FC | - | Sol de América | 0:0 |  |
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| 21. Round | 06/11/2022 | Libertad | - | Guaireña FC | 4:2 | |
Paraguay