| 1. Round | 23/01/2022 | Independiente Medellín | - | Deportes Tolima | 1:0 | ||||
| 2. Round | 26/01/2022 | Deportivo Cali | - | Deportes Tolima | 0:1 |  |
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| 3. Round | 01/02/2022 | Deportes Tolima | - | Unión Magdalena | 2:1 | ||||
| 4. Round | 04/02/2022 | Atlético Nacional | - | Deportes Tolima | 0:1 |  |
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| 5. Round | 06/02/2022 | Deportes Tolima | - | Atlético Bucaramanga | 2:1 | |
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| 7. Round | 16/02/2022 | Deportes Tolima | - | Santa Fe | 3:0 | ||||
| 11. Round | 16/03/2022 | Deportes Tolima | - | Patriotas FC | 1:2 | ||||
| 12. Round | 22/03/2022 | Once Caldas | - | Deportes Tolima | 2:2 | ||||
| 14. Round | 02/04/2022 | Deportivo Pereira | - | Deportes Tolima | 0:2 |  |
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| 16. Round | 16/04/2022 | Deportes Tolima | - | Deportivo Pasto | 0:1 | ||||
| 19. Round | 09/05/2022 | Millonarios | - | Deportes Tolima | 0:0 | ||||
| 20. Round | 15/05/2022 | Deportes Tolima | - | Envigado FC | 1:1 | |
Paraguay
Mexico