| 2. Round | 01/11/2021 | Al Masry Club | - | Smouha Sporting Club | 0:0 | ||||
| 3. Round | 05/11/2021 | Smouha Sporting Club | - | El Sharkia Lel Dokhan | 3:0 | ||||
| 4. Round | 19/11/2021 | ENPPI | - | Smouha Sporting Club | 1:1 |  |
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| 6. Round | 25/11/2021 | Al Ahly SC | - | Smouha Sporting Club | 4:1 | ||||
| 7. Round | 21/12/2021 | Smouha Sporting Club | - | Ismaily | 2:1 | ||||
| 5. Round | 25/12/2021 | Smouha Sporting Club | - | Tala'ea El Gaish SC | 1:0 |  |
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| 8. Round | 10/02/2022 | National Bank SC | - | Smouha Sporting Club | 1:2 | ||||
| 9. Round | 15/02/2022 | Smouha Sporting Club | - | Zamalek | 2:0 | ||||
| 10. Round | 21/02/2022 | Al Mokawloon | - | Smouha Sporting Club | 0:0 | ||||
| 11. Round | 27/02/2022 | Smouha Sporting Club | - | Ghazl Al Mehalla | 2:0 | ||||
| 12. Round | 08/03/2022 | Ceramica Cleopatra | - | Smouha Sporting Club | 1:1 | ||||
| 13. Round | 15/03/2022 | Future FC | - | Smouha Sporting Club | 4:0 | ||||
| 15. Round | 20/04/2022 | El Gouna | - | Smouha Sporting Club | 1:0 |
Egypt