| 1. Round | 23/10/2021 | RC Arbaâ | - | US Biskra | 0:5 | ||||
| 2. Round | 29/10/2021 | US Biskra | - | JS Saoura | 2:1 | ||||
| 3. Round | 07/11/2021 | US Biskra | - | RC Rélizane | 1:0 | ||||
| 5. Round | 25/11/2021 | US Biskra | - | HB Chelghoum Laïd | 2:0 | ||||
| 7. Round | 10/12/2021 | US Biskra | - | ASO Chlef | 2:1 | ||||
| 8. Round | 17/12/2021 | MC Oran | - | US Biskra | 2:2 | ||||
| 10. Round | 29/12/2021 | NC Magra | - | US Biskra | 1:0 | ||||
| 11. Round | 03/01/2022 | US Biskra | - | WA Tlemcen | 0:0 | ||||
| 12. Round | 07/01/2022 | MC Alger | - | US Biskra | 1:1 | ||||
| 17. Round | 05/02/2022 | US Biskra | - | NA Hussein Dey | 2:1 |
Algeria