| 2. Round | 28/01/2021 | ART Municipal Jalapa | - | Junior Managua | 1:1 |  |
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| 3. Round | 31/01/2021 | ART Municipal Jalapa | - | CD Walter Ferretti | 2:0 | ||||
| 5. Round | 08/02/2021 | ART Municipal Jalapa | - | Real Estelí FC | 2:1 | ||||
| 7. Round | 14/02/2021 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 3:3 | ||||
| 10. Round | 08/03/2021 | ART Municipal Jalapa | - | Juventus Managua | 1:0 | ||||
| 16. Round | 30/04/2021 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 2:0 | ||||
| 17. Round | 03/05/2021 | ART Municipal Jalapa | - | Chinandega | 1:1 | ||||
| 18. Round | 05/05/2021 | Real Madriz | - | ART Municipal Jalapa | 1:0 |
Nicaragua