| 5. Round | 30/08/2021 | Real Estelí FC | - | ART Municipal Jalapa | 2:0 | ||||
| 13. Round | 21/10/2021 | CD Walter Ferretti | - | ART Municipal Jalapa | 5:0 | ||||
| 14. Round | 24/10/2021 | ART Municipal Jalapa | - | Real Estelí FC | 2:1 | ||||
| 15. Round | 01/11/2021 | ART Municipal Jalapa | - | Real Madriz | 0:1 | ||||
| 16. Round | 04/11/2021 | H&H Export Sébaco | - | ART Municipal Jalapa | 3:0 | ||||
| 18. Round | 22/11/2021 | Diriangén FC | - | ART Municipal Jalapa | 5:0 |
Nicaragua