| 1. Round | 12/03/2021 | Real Tomayapo | - | Always Ready | 1:0 |  |
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| 2. Round | 14/03/2021 | Always Ready | - | Club San José | 5:0 | ||||
| 3. Round | 03/04/2021 | Real Santa Cruz | - | Always Ready | 2:3 | ||||
| 4. Round | 10/04/2021 | Always Ready | - | Nacional Potosí | 1:1 | |
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| 18. Round | 14/09/2021 | Always Ready | - | Real Santa Cruz | 4:0 | ||||
| 19. Round | 19/09/2021 | Nacional Potosí | - | Always Ready | 0:2 | ||||
| 20. Round | 23/09/2021 | Always Ready | - | Oriente Petrolero | 2:0 | ||||
| 21. Round | 27/09/2021 | The Strongest | - | Always Ready | 1:1 | ||||
| 23. Round | 24/10/2021 | Atlético Palmaflor | - | Always Ready | 0:1 | ||||
| 24. Round | 27/10/2021 | Always Ready | - | Independiente Petrolero | 2:2 | |
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| 25. Round | 31/10/2021 | Always Ready | - | Royal Pari | 2:1 | |
Panama