| 40. Round | 21/08/2021 | Solihull Moors | - | Wrexham AFC | 2:2 | ||||
| 2. Round | 28/08/2021 | Eastleigh FC | - | Wrexham AFC | 0:2 |  |
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| 4. Round | 04/09/2021 | Southend United | - | Wrexham AFC | 2:2 | ||||
| 5. Round | 11/09/2021 | Wrexham AFC | - | Woking FC | 1:0 | ||||
| 7. Round | 18/09/2021 | Wrexham AFC | - | Dagenham & Redbridge | 1:0 | ||||
| 8. Round | 25/09/2021 | Stockport County | - | Wrexham AFC | 2:1 | |
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| 10. Round | 05/10/2021 | Wrexham AFC | - | Chesterfield FC | 1:1 | ||||
| 14. Round | 30/10/2021 | Wrexham AFC | - | Torquay United | 1:1 |  |
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| 9. Round | 09/11/2021 | Aldershot Town | - | Wrexham AFC | 0:5 | |
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| 15. Round | 13/11/2021 | King's Lynn | - | Wrexham AFC | 2:6 | ||||
| 16. Round | 20/11/2021 | Wrexham AFC | - | Wealdstone FC | 0:0 | ||||
| 18. Round | 27/11/2021 | Wrexham AFC | - | Bromley FC | 2:0 | ||||
| 1. Round | 30/11/2021 | Wrexham AFC | - | Yeovil Town | 0:2 | |
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| 19. Round | 04/12/2021 | Dover Athletic | - | Wrexham AFC | 0:1 | |
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| 22. Round | 28/12/2021 | Altrincham FC | - | Wrexham AFC | 0:2 | |
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| 23. Round | 02/01/2022 | Notts County | - | Wrexham AFC | 3:1 |  |
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| 25. Round | 22/01/2022 | Yeovil Town | - | Wrexham AFC | 1:2 |
England