| 9. Round | 24/12/2021 | US Biskra | - | CR Bélouizdad | 0:1 | ||||
| 10. Round | 29/12/2021 | NC Magra | - | US Biskra | 1:0 | ||||
| 18. Round | 25/02/2022 | US Biskra | - | RC Arbaâ | 1:0 | ||||
| 20. Round | 05/03/2022 | RC Rélizane | - | US Biskra | 1:1 | ||||
| 23. Round | 28/03/2022 | US Biskra | - | JS Kabylie | 0:1 | ||||
| 24. Round | 01/04/2022 | ASO Chlef | - | US Biskra | 2:0 | ||||
| 27. Round | 22/04/2022 | US Biskra | - | NC Magra | 1:0 | ||||
| 28. Round | 29/04/2022 | WA Tlemcen | - | US Biskra | 0:3 | ||||
| 29. Round | 07/05/2022 | US Biskra | - | MC Alger | 0:0 | ||||
| 30. Round | 14/05/2022 | CS Constantine | - | US Biskra | 0:0 | ||||
| 33. Round | 05/06/2022 | US Biskra | - | ES Sétif | 1:1 | ||||
| 34. Round | 10/06/2022 | NA Hussein Dey | - | US Biskra | 1:2 |
Algeria