| 1. Round | 12/12/2020 | Al Mokawloon | - | Zamalek | 0:2 | ||||
| 2. Round | 16/12/2020 | Wadi Degla SC | - | Al Mokawloon | 2:1 |  |
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| 3. Round | 12/01/2021 | Al Mokawloon | - | Ceramica Cleopatra | 1:1 |  |
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| 7. Round | 15/01/2021 | Pyramids FC | - | Al Mokawloon | 3:1 | |
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| 9. Round | 21/01/2021 | Al Ahly SC | - | Al Mokawloon | 3:2 | ||||
| 8. Round | 26/01/2021 | Al Mokawloon | - | Smouha Sporting Club | 1:2 | ||||
| 11. Round | 03/02/2021 | Tala'ea El Gaish SC | - | Al Mokawloon | 1:1 | ||||
| 16. Round | 14/03/2021 | Al Mokawloon | - | Ghazl Al Mehalla | 0:1 | ||||
| 30. Round | 12/08/2021 | Al Mokawloon | - | El Gouna | 2:1 | ||||
| 31. Round | 16/08/2021 | Aswan SC | - | Al Mokawloon | 1:2 | ||||
| 32. Round | 21/08/2021 | Al Mokawloon | - | Misr lel-Maqasah SC | 3:2 |
Tunisia