| 5. Round | 22/11/2021 | Zamalek | - | National Bank SC | 1:1 | ||||
| 6. Round | 25/11/2021 | Ceramica Cleopatra | - | Zamalek | 0:1 | ||||
| 7. Round | 21/12/2021 | Al Mokawloon | - | Zamalek | 1:2 | ||||
| 8. Round | 25/12/2021 | Zamalek | - | Ghazl Al Mehalla | 4:0 | ||||
| 10. Round | 02/03/2022 | Zamalek | - | Future FC | 3:2 | ||||
| 12. Round | 07/03/2022 | Zamalek | - | El Gouna | 2:1 | ||||
| 11. Round | 06/04/2022 | Pyramids FC | - | Zamalek | 2:3 | ||||
| 13. Round | 09/04/2022 | Misr lel-Maqasah SC | - | Zamalek | 0:1 | ||||
| 14. Round | 12/04/2022 | Zamalek | - | Pharco FC | 0:0 | ||||
| 17. Round | 01/05/2022 | El Sharkia Lel Dokhan | - | Zamalek | 1:2 | ||||
| 18. Round | 10/05/2022 | Zamalek | - | ENPPI | 0:2 | ||||
| 19. Round | 17/05/2022 | Zamalek | - | Tala'ea El Gaish SC | 0:1 | ||||
| 21. Round | 28/05/2022 | Zamalek | - | Ismaily | 2:1 | ||||
| 26. Round | 24/07/2022 | Zamalek | - | Smouha Sporting Club | 2:0 | ||||
| 28. Round | 01/08/2022 | Zamalek | - | Pyramids FC | 3:0 | ||||
| 29. Round | 05/08/2022 | El Gouna | - | Zamalek | 1:4 | ||||
| 32. Round | 23/08/2022 | Zamalek | - | Ittihad El Iskandary | 1:1 | ||||
| 33. Round | 26/08/2022 | Al Masry Club | - | Zamalek | 0:0 |
Egypt