| 7. Round | 06/09/2020 | Real Madriz | - | Junior Managua | 1:1 | ||||
| 8. Round | 14/09/2020 | Juventus Managua | - | Real Madriz | 1:0 | ||||
| 9. Round | 21/09/2020 | Real Madriz | - | ART Municipal Jalapa | 3:0 | ||||
| 10. Round | 28/09/2020 | Real Madriz | - | CD Walter Ferretti | 2:2 |  |
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| 11. Round | 01/10/2020 | Diriangén FC | - | Real Madriz | 3:1 | ||||
| 13. Round | 26/10/2020 | Managua FC | - | Real Madriz | 0:1 | ||||
| 15. Round | 01/11/2020 | Chinandega | - | Real Madriz | 1:1 | ||||
| 17. Round | 15/11/2020 | Real Madriz | - | Juventus Managua | 1:1 | ||||
| 18. Round | 20/11/2020 | ART Municipal Jalapa | - | Real Madriz | 2:1 |
Honduras