| 6. Round | 10/02/2022 | AD Chalatenango | - | Once Municipal | 1:0 | ||||
| 8. Round | 20/02/2022 | AD Chalatenango | - | Jocoro FC | 1:0 | ||||
| 9. Round | 23/02/2022 | FAS | - | AD Chalatenango | 1:3 | ||||
| 10. Round | 27/02/2022 | AD Chalatenango | - | Santa Tecla FC | 1:0 | ||||
| 13. Round | 20/03/2022 | AD Chalatenango | - | Isidro Metapán | 1:1 | ||||
| 14. Round | 25/03/2022 | AD Chalatenango | - | Alianza | 2:0 | ||||
| 15. Round | 03/04/2022 | Luis Ángel Firpo | - | AD Chalatenango | 1:2 |  |
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| 16. Round | 10/04/2022 | AD Chalatenango | - | Platense Zacatecoluca | 1:2 | ||||
| 17. Round | 13/04/2022 | Once Municipal | - | AD Chalatenango | 0:1 | ||||
| 18. Round | 17/04/2022 | AD Chalatenango | - | CD Águila | 0:0 | ||||
| 19. Round | 24/04/2022 | Jocoro FC | - | AD Chalatenango | 6:5 | |
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| 20. Round | 28/04/2022 | AD Chalatenango | - | FAS | 3:2 | |
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| 21. Round | 01/05/2022 | Santa Tecla FC | - | AD Chalatenango | 1:0 | ||||
| 22. Round | 07/05/2022 | AD Chalatenango | - | Municipal Limeño | 0:0 |
El Salvador