| 1. Round | 24/01/2021 | Juventus Managua | - | ART Municipal Jalapa | 3:1 | ||||
| 2. Round | 28/01/2021 | CD Walter Ferretti | - | Juventus Managua | 1:0 |  |
|||
| 3. Round | 31/01/2021 | Juventus Managua | - | Diriangén FC | 1:0 | ||||
| 5. Round | 07/02/2021 | Juventus Managua | - | Managua FC | 0:5 | ||||
| 6. Round | 11/02/2021 | Club Deportivo Ocotal | - | Juventus Managua | 1:0 | ||||
| 7. Round | 14/02/2021 | Juventus Managua | - | Chinandega | 1:3 | ||||
| 9. Round | 01/03/2021 | Junior Managua | - | Juventus Managua | 1:2 | |
|||
| 11. Round | 14/03/2021 | Juventus Managua | - | CD Walter Ferretti | 1:2 | ||||
| 13. Round | 23/04/2021 | Real Estelí FC | - | Juventus Managua | 4:0 |
Nicaragua