| Group 1 | 11/10/2020 | Isidro Metapán | - | FAS | 3:1 |  |
|||
| Group 1 | 18/10/2020 | Isidro Metapán | - | Once Municipal | 6:0 | ||||
| Group 1 | 24/10/2020 | Sonsonate FC | - | Isidro Metapán | 1:1 | |
|||
| Group 1 | 01/11/2020 | FAS | - | Isidro Metapán | 4:0 | ||||
| Group 1 | 15/11/2020 | Isidro Metapán | - | Sonsonate FC | 2:0 | ||||
| Group A | 22/11/2020 | Sonsonate FC | - | Isidro Metapán | 1:1 | ||||
| Group A | 26/11/2020 | Isidro Metapán | - | CD Águila | 0:1 | ||||
| Group A | 29/11/2020 | Atlético Marte | - | Isidro Metapán | 1:1 |  |
|||
| Group A | 06/12/2020 | Isidro Metapán | - | Alianza | 1:1 | |
|||
| Group A | 12/12/2020 | Jocoro FC | - | Isidro Metapán | 3:1 | ||||
| Group A | 20/12/2020 | Isidro Metapán | - | Sonsonate FC | 2:3 | |
|||
| Group A | 23/12/2020 | CD Águila | - | Isidro Metapán | 3:1 |  |
|||
| Group A | 03/01/2021 | Alianza | - | Isidro Metapán | 1:0 | ||||
| Group A | 09/01/2021 | Isidro Metapán | - | Jocoro FC | 0:0 |
El Salvador