| Group 1 | 14/02/2021 | Isidro Metapán | - | FAS | 2:1 | ||||
| Group 1 | 18/02/2021 | Isidro Metapán | - | Once Municipal | 1:1 | ||||
| Group 1 | 21/02/2021 | Sonsonate FC | - | Isidro Metapán | 0:3 | ||||
| Group 1 | 07/03/2021 | FAS | - | Isidro Metapán | 0:1 | ||||
| Group 1 | 09/03/2021 | Once Municipal | - | Isidro Metapán | 1:0 | ||||
| Group 1 | 14/03/2021 | Isidro Metapán | - | Sonsonate FC | 0:2 | ||||
| Group B | 20/03/2021 | CD Águila | - | Isidro Metapán | 0:2 |  |
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| Group B | 01/04/2021 | Isidro Metapán | - | Santa Tecla FC | 1:2 | |
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| Group B | 04/04/2021 | Sonsonate FC | - | Isidro Metapán | 0:1 | ||||
| Group B | 08/04/2021 | Isidro Metapán | - | AD Chalatenango | 1:0 | ||||
| Group B | 11/04/2021 | Municipal Limeño | - | Isidro Metapán | 2:1 | |
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| Group B | 18/04/2021 | Isidro Metapán | - | CD Águila | 1:1 | ||||
| Group B | 22/04/2021 | Santa Tecla FC | - | Isidro Metapán | 3:1 |  |
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| Group B | 28/04/2021 | AD Chalatenango | - | Isidro Metapán | 0:4 | |
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| Group B | 01/05/2021 | Isidro Metapán | - | Municipal Limeño | 2:0 | ||||
| Quarter-finals | 05/05/2021 | Luis Ángel Firpo | - | Isidro Metapán | 1:0 | ||||
| Quarter-finals | 09/05/2021 | Isidro Metapán | - | Luis Ángel Firpo | 1:3 |
El Salvador