| 1. Round | 01/08/2021 | Isidro Metapán | - | Atlético Marte | 0:0 | ||||
| 2. Round | 08/08/2021 | Santa Tecla FC | - | Isidro Metapán | 3:0 | ||||
| 3. Round | 12/08/2021 | Isidro Metapán | - | CD Águila | 2:2 |  |
|||
| 4. Round | 14/08/2021 | Jocoro FC | - | Isidro Metapán | 1:0 | |
|||
| 5. Round | 22/08/2021 | Isidro Metapán | - | Municipal Limeño | 1:0 | ||||
| 7. Round | 29/08/2021 | Isidro Metapán | - | Alianza | 1:2 | ||||
| 8. Round | 12/09/2021 | Luis Ángel Firpo | - | Isidro Metapán | 1:1 | ||||
| 9. Round | 16/09/2021 | Isidro Metapán | - | Once Municipal | 0:1 |
El Salvador