| 3. Round | 30/01/2022 | Deportivo Malacateco | - | Cobán Imperial | 0:0 |  |
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| 4. Round | 02/02/2022 | Cobán Imperial | - | Xelaju MC | 3:1 |  |
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| 5. Round | 05/02/2022 | Nueva Concepción | - | Cobán Imperial | 1:2 | |
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| 6. Round | 10/02/2022 | Antigua GFC | - | Cobán Imperial | 0:1 | ||||
| 7. Round | 12/02/2022 | Cobán Imperial | - | Iztapa | 2:0 | |
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| 8. Round | 19/02/2022 | CSD Municipal | - | Cobán Imperial | 3:2 | ||||
| 9. Round | 27/02/2022 | Cobán Imperial | - | Achuapa | 0:1 | ||||
| 10. Round | 02/03/2022 | Santa Lucía | - | Cobán Imperial | 2:1 | ||||
| 11. Round | 06/03/2022 | Cobán Imperial | - | Deportivo Guastatoya | 0:0 | ||||
| 12. Round | 12/03/2022 | Cobán Imperial | - | Sololá FC | 2:1 | ||||
| 13. Round | 20/03/2022 | Comunicaciones | - | Cobán Imperial | 1:4 | ||||
| 14. Round | 26/03/2022 | Cobán Imperial | - | Deportivo Malacateco | 1:1 | ||||
| 19. Round | 13/04/2022 | Cobán Imperial | - | CSD Municipal | 1:1 | ||||
| 18. Round | 20/04/2022 | Iztapa | - | Cobán Imperial | 3:0 |
Argentina