| 1. Round | 24/01/2021 | Juventus Managua | - | ART Municipal Jalapa | 3:1 | ||||
| 8. Round | 18/02/2021 | Chinandega | - | ART Municipal Jalapa | 1:1 | ||||
| 10. Round | 08/03/2021 | ART Municipal Jalapa | - | Juventus Managua | 1:0 | ||||
| 13. Round | 12/04/2021 | ART Municipal Jalapa | - | Diriangén FC | 0:2 | ||||
| 14. Round | 20/04/2021 | Real Estelí FC | - | ART Municipal Jalapa | 1:0 |  |
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| 15. Round | 26/04/2021 | ART Municipal Jalapa | - | Managua FC | 2:2 | ||||
| 16. Round | 30/04/2021 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 2:0 | |
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| 18. Round | 05/05/2021 | Real Madriz | - | ART Municipal Jalapa | 1:0 |
Nicaragua