| 1. Round | 02/08/2021 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 1:1 |  |
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| 3. Round | 15/08/2021 | UNAN Managua | - | ART Municipal Jalapa | 1:0 | ||||
| 4. Round | 22/08/2021 | ART Municipal Jalapa | - | CD Walter Ferretti | 2:0 | ||||
| 8. Round | 20/09/2021 | Juventus Managua | - | ART Municipal Jalapa | 3:1 | ||||
| 11. Round | 10/10/2021 | Managua FC | - | ART Municipal Jalapa | 3:0 | ||||
| 12. Round | 18/10/2021 | ART Municipal Jalapa | - | UNAN Managua | 2:2 | ||||
| 13. Round | 21/10/2021 | CD Walter Ferretti | - | ART Municipal Jalapa | 5:0 | ||||
| 16. Round | 04/11/2021 | H&H Export Sébaco | - | ART Municipal Jalapa | 3:0 | ||||
| 17. Round | 19/11/2021 | ART Municipal Jalapa | - | Juventus Managua | 1:1 | |
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| 18. Round | 22/11/2021 | Diriangén FC | - | ART Municipal Jalapa | 5:0 |
Nicaragua