| 2. Round | 24/10/2021 | AS Rejiche | - | US Monastir | 0:1 | ||||
| 3. Round | 31/10/2021 | US Monastir | - | Étoile du Sahel | 1:0 | ||||
| 4. Round | 04/11/2021 | AS Soliman | - | US Monastir | 0:0 |  |
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| 5. Round | 07/11/2021 | US Monastir | - | Club Africain | 0:0 | ||||
| 6. Round | 18/11/2021 | US Monastir | - | Olympique Béja | 2:1 | ||||
| 13. Round | 10/04/2022 | Olympique Béja | - | US Monastir | 0:0 | ||||
| 14. Round | 13/04/2022 | US Monastir | - | Espérance Zarzis | 0:1 |
Tunisia